image

7.2.1. Normal reference intervals

Chapter 7

Normal reference intervals for κ sFLCs, λ sFLCs and the κ/λ sFLC ratio were published by Katzmann et al. . These ranges have been locally validated and widely adopted by many centres and are further discussed in Chapter 6. For patients with renal impairment, application of a modified renal reference interval may increase the specificity of the κ/λ sFLC ratio for detecting monoclonal FLC production (Section 6.3).