Monitoring multiple myeloma with Hevylite assays
IgA Hevylite can substitute for SPE, IFE and total IgA measurements for monitoring β-migrating IgA monoclonal proteins .
1. Katzmann JA et al. Clin Chem. 2015;61:360-7 Read more
Smouldering multiple myeloma requiring treatment: a new definition
Patients with the highest-risk smouldering multiple myeloma have been reclassified as active multiple myeloma, so that they can receive appropriate therapy .
1. Rajkumar SV et al. Lancet Oncology 2014;15:e538-e548 Read more
Nephrotoxicity of monoclonal FLCs
sFLC analysis is useful for screening for monoclonal gammopathy of renal significance .
1. Yadav P et al. Kidney Int 2014 In press
2. Merlini G et al. Contrib Nephrol 2007;153:66-86 Read more
FLCs in cerebrospinal fluid
An elevated κ FLC index can support a diagnosis of multiple sclerosis .
1. Presslauer S et al. PLoS ONE 2014;9:e89945 Read more
Over the past twelve years, there have been seven editions of the monograph entitled, Serum Free Light Chain Analysis (plus Hevylite). With the ever expanding literature on serum free light chains and Hevylite, each new edition of the book quickly becomes out of date. Hence, Wikilite.com, an online resource in which the hundreds of new publications are reviewed and rapidly integrated into a changing and challenging subject.
All are familiar with Wikipedia. It has some superb features such as a great search engine, hyperlinks with the literature, and an escalating data base. Furthermore, it can be accessed by all without the need to destroy a rain forest. This format seems to be an ideal way to present the latest information on Serum Free Light Chain Analysis plus Hevylite.
Wikilite.com is available on a read-only basis. The revision process involves a team of clinical and scientific staff at Binding Site working together to provide updates on their specific areas of expertise. There is also a chief editor who provides consistency of content and style and monitors updates on a continuous basis. In this manner, we intend to maintain a fully up-to-date literature review for all those who are interested in Serum Free Light Chain Analysis and Hevylite.
Unless stated clearly to the contrary, all quantitative serum free light chain data within Wikilite has been generated using Freelite® kits manufactured by The Binding Site and all guidelines and proposed clinical utilities have been based upon Freelite data.
In some countries, products intended for measurement of serum free light chains, have been made available by other manufacturers. Trials of such products have produced poor correlations with free light chain concentrations determined using Freelite. Therefore, it cannot be assumed that other products will have the same clinical utility or give compliance with current guidelines, such as those issued by the International Myeloma Working Group (IMWG) and the National Comprehensive Cancer Network (NCCN).