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From Wikilite
Welcome to wikilite.com - an online educational resource with continuously updated information on serum free light chain and Hevylite™ analysis.
Use the links on this page to navigate to the Contents page or featured articles below to explore the site contents.
Featured Chapter
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13 |
SECTION 2A - Multiple Myeloma |
| The kidney and monoclonal free light chains |
Chapter 13 highlights the nephrotoxicity of monoclonal free light chains. Intensive FLC removal by “protein-leaking” dialysers when used in combination with effective chemotherapy may improve renal recovery rates in patients with cast nephropathy and dialysis-dependent acute renal failure.
Featured Chapter
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32 |
SECTION 6 - Appendices |
| Analysis of immunoglobulin heavy chain/light chain pairs (Hevylite) |
Chapter 32 introduces new immunoglobulin heavy chain/light chain immunoassays “Hevylite” (HLC) for monitoring monoclonal gammopathies. Pairs of HLC reagents (e.g. IgAκ/IgAλ) produce ratios of monoclonal immunoglobulin to background polyclonal immunoglobulin concentrations in the same manner as serum FLC ratios.
Wikilite.com: Preface
Over the past six years, there have been five editions of the monograph entitled, Serum Free Light Chain Analysis. Writing a sixth edition would change a pleasure into an obsession. Hundreds of publications need to be reviewed and integrated into a changing and challenging subject. Sharing the task with others would introduce different issues such as editing, re-writing and style uniformity; but it would not solve the problems of integrating the ever expanding literature. Hence, Wikilite.com.
All are familiar with Wikipedia. It has some superb features such as a great search engine, hyperlinks with the literature, and an escalating data base. Furthermore, it can be accessed by all without the need to destroy a rain forest. This format seems to be an ideal way to present the sixth edition of Serum Free Light Chain Analysis.
Wikilite.com is available on a read-only basis. This first electronic version is a direct transfer from the 5th edition of the book that was published in June 2008. Future changes will be undertaken by members of the clinical and scientific teams at Binding Site. There is a chief editor who will provide consistency of content and style and monitor updates on a continuous basis. In this manner, my colleagues and I intend to maintain a fully up-to-date literature review for all those who are interested in Serum Free Light Chain Analysis (and Hevylite).
AR Bradwell July 2009
