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Welcome to - an online educational resource with continually updated information on serum free light chain (Freelite®) and Hevylite® analysis.

Use the links on this page to navigate to the Contents page or featured articles below to explore the site contents.

Featured Chapter



SECTION 2 - Multiple Myeloma

The kidney and monoclonal free light chains

Chapter 13 highlights the nephrotoxicity of monoclonal free light chains. Intensive FLC removal by “protein-leaking” dialysers when used in combination with effective chemotherapy may improve renal recovery rates in patients with cast nephropathy and dialysis-dependent acute renal failure.

Featured Chapter



SECTION 13 - Introduction

Analysis of immunoglobulin heavy chain/light chain pairs (Hevylite)

Chapter 32 introduces new immunoglobulin heavy chain/light chain immunoassays “Hevylite” (HLC) for monitoring monoclonal gammopathies. Pairs of HLC reagents (e.g. IgAκ/IgAλ) produce ratios of monoclonal immunoglobulin to background polyclonal immunoglobulin concentrations in the same manner as serum FLC ratios.

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Gap text Preface

Graph showing increasing serum free light chain publications per year, from 1999 to present

Over the past eight years, there have been six editions of the monograph entitled, Serum Free Light Chain Analysis (plus Hevylite). With the ever expanding literature on serum free light chains and Hevylite, each new edition of the book quickly becomes out of date. Hence,, an online resource in which the hundreds of new publications are reviewed and rapidly integrated into a changing and challenging subject.

All are familiar with Wikipedia. It has some superb features such as a great search engine, hyperlinks with the literature, and an escalating data base. Furthermore, it can be accessed by all without the need to destroy a rain forest. This format seems to be an ideal way to present the latest information on Serum Free Light Chain Analysis plus Hevylite. is available on a read-only basis. The revision process involves a team of clinical and scientific staff at Binding Site working together to provide updates on their specific areas of expertise. There is also a chief editor who provides consistency of content and style and monitors updates on a continuous basis. In this manner, my colleagues and I intend to maintain a fully up-to-date literature review for all those who are interested in Serum Free Light Chain Analysis and Hevylite.

AR Bradwell, January 2011

Important Notice

Unless stated clearly to the contrary, all quantitative serum free light chain data within Wikilite has been generated using Freelite® kits manufactured by The Binding Site and all guidelines and proposed clinical utilities have been based upon Freelite data.

In some countries, products intended for measurement of serum free light chains, have been made available by other manufacturers. Trials of such products have produced poor correlations with free light chain concentrations determined using Freelite. Therefore, it cannot be assumed that other products will have the same clinical utility or give compliance with current guidelines, such as those issued by the International Myeloma Working Group (IMWG) and the National Comprehensive Cancer Network (NCCN).

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