Contents

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Contents

Contents

Overview - The clinical importance of serum free light chain analysis

SECTION 1 - Immunoglobulin free light chains and their analysis

Chapter 1 - Introduction
Chapter 2 - Dr Bence Jones and the history of free light chains
Chapter 3 - Biology of immunoglobulin light chains
Chapter 4 - Immunoassays for free light chain measurement
Chapter 5 - Normal ranges and reference intervals
Chapter 6 - Sensitivity of serum free light chain assays

SECTION 2 - Free light chains and monoclonal gammopathies

Chapter 7 - Multiple myeloma (MM) - Introduction
Chapter 8 - Light chain multiple myeloma (LCMM)
Chapter 9 - Nonsecretory multiple myeloma (NSMM)
Chapter 10 - Intact immunoglobulin multiple myeloma (IIMM) - theoretical considerations of sFLC and Ig measurements
Chapter 11 - Intact immunoglobulin MM (IIMM) - sFLCs at diagnosis
Chapter 12 - Monitoring IIMM patients using sFLCs
Chapter 13 - The kidney and monoclonal free light chains
Chapter 14 - Asymptomatic (smouldering) multiple myeloma (ASMM)
Chapter 15 - AL Amyloidosis
Chapter 16 - Localised amyloid disease
Chapter 17 - Light chain deposition disease (LCDD)
Chapter 18 - Other malignancies with monoclonal FLCs
Chapter 19 - Monoclonal gammopathies of undetermined significance (MGUS)

SECTION 3 - Diseases with increased polyclonal free light chains

Chapter 20 - Renal diseases and free light chains
Chapter 21 - Immune stimulation and elevated polyclonal free light chains
Chapter 22 - Cerebrospinal fluid and free light chains

SECTION 4 - General applications of free light chain assays

Chapter 23 - Screening studies using serum free light chain analysis
Chapter 24 - Serum versus urine tests for free light chains
Chapter 25 - Guidelines for use of serum free light chain assays

SECTION 5 - Practical aspects of serum free light chain testing

Chapter 26 - Implementation and interpretation of free light chain assays
Chapter 27 - Instrumentation for free light chain immunoassays
Chapter 28 - Quality assurance for serum free light chain analysis

SECTION 6 - Appendices

Chapter 29 - Classification of diseases with increased immunoglobulins
Chapter 30 - Questions and answers about FLCs
Chapter 31 - Serum free light chain publications
Chapter 32 - Analysis of immunoglobulin heavy chain/light chain pairs (Hevylite™)

Preface and Abbreviations

Preface to 5th edition
Preface to 1st edition 2003
Dedication and Acknowledgements
Abbreviations
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